A Comparison of Methods to Determine Neuronal Phase-Response Curves
نویسندگان
چکیده
The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both model data and experimental data and compare the numerically obtained results from each method. The main difference between the methods lies in the reliability which is influenced by the fluctuations in the spiking data and the number of spikes available for analysis. We discuss the significance of our results and provide guidelines to choose the best method based on the available data.
منابع مشابه
The firing rate of neurons in the nucleus cuneiformis in response to formalin in male rat
Introduction: Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the midbrain neural basis underlying each phase of behavior in formalin test has not been clarified. The present study was designed to investigate the nucleus cuneiformis (CnF) neuronal responses during two phases after subcutaneous injection of formalin into the hind paw...
متن کاملFragility Curves for Reinforced Concrete Frames with Lap-Spliced Columns
Placing column lap-splice in the locations of possible nonlinear deformation may adversely affect the structures response to strong ground motions. Localization of damage in splice zone may change the structural response and prevent the load redistribution and development of a uniform pattern of nonlinear excursions among the various members. Validated by existing laboratory experiments, this s...
متن کاملComparison of Three Staining Methods of Vibratome and Paraffin Sections in Preserving Thickness of Rat Hippocampal Sections
Purpose: To determine the optimal technique for maintaining hippocampus vibratome sections volume. Materials and Methods: This experimental study was performed on three rat hippocampus. The first hippocampus was embedded in paraffin and using rotary microtome forty sections were cut in a nominal thickness of 100 micrometer. They were then ordinary stained. The two others were cut into 80 sectio...
متن کاملPhase response curves elucidating the dynamics of coupled oscillators.
Phase response curves (PRCs) are widely used in circadian clocks, neuroscience, and heart physiology. They quantify the response of an oscillator to pulse-like perturbations. Phase response curves provide valuable information on the properties of oscillators and their synchronization. This chapter discusses biological self-sustained oscillators (circadian clock, physiological rhythms, etc.) in ...
متن کاملDesynchronization of stochastically synchronized chemical oscillators.
Experimental and theoretical studies are presented on the design of perturbations that enhance desynchronization in populations of oscillators that are synchronized by periodic entrainment. A phase reduction approach is used to determine optimal perturbation timing based upon experimentally measured phase response curves. The effectiveness of the perturbation waveforms is tested experimentally ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2010